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DOMAINS / BIO-INFORMATICS / NEXT GENERATION SEQUENCING (NGS)

Empowering Bioinformatics Through Computational Intelligence

Bioinformatics

Developing Secure, Compliant Platforms for Clinical Genomic Data Management

Next Generation Sequencing (NGS)

Next Generation Sequencing (NGS), A high-throughput sequencing technology that has revolutionized genomics and molecular biology research. The massively parallel or deep sequencing allows researchers to sequence millions of DNA fragments simultaneously, enabling rapid and cost-effective analysis of entire genomes, transcriptase, and epic genomes. At UVJ, we have the expertise in leveraging software solutions & tools for the rapid sequencing of large amounts of DNA or RNA.

UVJ’s Key Software Solution Capabilities in Next Generation Sequencing (NGS)

Whole Genome Sequencing (WGS)

WGS: Provides a comprehensive view of an individual's genetic makeup, allowing for the detection of genetic variations, mutations, and copy number changes. Its applications include disease diagnosis, personalized medicine, and genetic research.

RNA Sequencing (RNA-Seq)

RNA-Seq allows researchers to study gene expression, identify regulatory elements, and understand complex biological processes in fields like cancer research, developmental biology, and rare disease diagnosis.

ChIP-Seq

ChIP-Seq identifies the binding sites of DNA-associated proteins and has been widely applied in fields such as developmental biology, cancer research, and epigenetics.

Metagenomics

Metagenomics includes the study of genetic material recovered directly from environmental samples, such as soil, ocean water, etc. It helps to facilitate the discovery of new enzymes and antibiotics, providing insights into the evolution of microbial communities and their interactions with the environment.

Cancer Genomics

Cancer Genomics helps to understand the genomic landscape of cancer; researchers can identify potential therapeutic targets, develop personalized treatment strategies, and improve treatment results. It also aids in more accurate disease diagnosis, monitoring, and prevention methods.

We are familiar in handling various file formats in NGS like fastaQ, vcf, bam, sam, bed etc.

Healthcare and Medicine

Personalized Medicine: Tailoring treatments based on individual genetic profiles (e.g., cancer genomics).

Disease Diagnosis: Identifying genetic mutations associated with inherited diseases

Drug Development: Analyzing genetic data to discover drug targets and develop new therapies.

Agriculture

Crop Improvement: Identifying genetic traits for disease resistance, drought tolerance, and improved yield.

Animal Breeding: Enhancing livestock genetics by selecting for favorable traits using NGS data.

Microbial Genomics: Understanding soil and plant-associated microbial communities to optimize farming.

Pharmaceuticals

Drug Discovery: Using NGS to identify genetic targets for drug development.

Pharmacogenomics: Studying how genetic variations influence individual responses to drugs.

Clinical Trials: NGS data is used for patient stratification and monitoring during trials.

Environmental Science

Biodiversity Studies: Sequencing environmental samples to identify species and monitor ecosystems.

Metagenomics: Analyzing microbial communities in environmental samples (e.g., soil, water) to understand ecological dynamics

Pollution Monitoring: Detecting microbial populations that respond to environmental pollutants.

Forensics

Genetic Profiling: Using NGS for highly accurate DNA fingerprinting in criminal investigations.

Ancestry and Lineage: Identifying genetic relationships and population origins in forensic studies.

Biothreat Detection: Rapid identification of pathogenic organisms in biodefense and public health.

Biotechnology

Synthetic Biology: Designing and modifying organisms for industrial applications using NGS data.

Industrial Microbiology: Optimizing microbial strains for the production of biofuels, enzymes, and other industrial products.

Gene Editing: Validating CRISPR and other gene-editing techniques with NGS.